Journal: Molecular Neurodegeneration
Article Title: Variants in the MS4A cluster interact with soluble TREM2 expression on biomarkers of neuropathology
doi: 10.1186/s13024-024-00727-7
Figure Lengend Snippet: TREM2 X rs6591561 interaction on Aβ 1-38 in ROS/ MAP. A TREM2 mRNA expression from the dorsolateral prefrontal cortex (dlPFC) is positively associated with Aβ 1-38 as measured by single reaction monitoring mass spectrometry (SRM) β = 0.09, p = 0.03. B TREM2 dlPFC mRNA expression association with Aβ 1-38 is driven by non-carriers of rs6591561 G minor allele (β = -0.20, p = 0.02)
Article Snippet: Biotinylated polyclonal goat anti-human TREM2 capture antibodies (R&D Systems BAF1828) were incubated with recombinant human TREM2 protein (Sino Biological Inc. 11084-H08H) and a SULFO-TAG–labeled anti-mouse secondary antibody was used for detection.
Techniques: Expressing, Mass Spectrometry